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Get Seal


Seal is developed by: crs4 logo

And generously hosted by Get SEAL at Fast, secure and Free Open Source software downloads
and GitHub

Additional Information


Although Seal doesn’t come with any guarantee of support or warranty, feel free to contact us if you have any problems installing or using it. We’ll try to help.

Known Issues

Seqal doesn’t run on 32-bit platforms

We have tested Seqal on 32-bit platforms and have found it not to run. We haven’t made this issue a priority since we expect most users to be running on a 64-bit platform.

Seal doesn’t handle single reads

At the moment PairReadsQSeq and Seqal only work with paired reads. If you want to align single reads, you can “hackishly” assemble a prq file that contains the same read as 1 and 2 and feed it to Seqal.


Seal is written at CRS4 by:

The alignment algorithm is implemented in libbwa, which is a modified and refactored version of the BWA short read aligner.

Citing Seal

If you use Seal in your work, please cite:

L. Pireddu, S. Leo, and G. Zanetti. MapReducing a genomic sequencing workflow. In Proceedings of the 20th ACM International Symposium on High Performance Distributed Computing, pages 67–74, June 2011.


 author = {Pireddu, Luca and Leo, Simone and Zanetti, Gianluigi},
 title = {MapReducing a genomic sequencing workflow},
 booktitle = {Proceedings of the second international workshop on MapReduce and its applications},
 series = {MapReduce '11},
 year = {2011},
 isbn = {978-1-4503-0700-0},
 location = {San Jose, California, USA},
 pages = {67--74},
 numpages = {8},
 url = {},
 doi = {},
 acmid = {1996106},
 publisher = {ACM},
 address = {New York, NY, USA},
 keywords = {MapReduce, next-generation sequencing, sequence alignment},


Seal is released under the GPLv3 license.